Nichirei has been granted a patent for a tissue slice selection method and embedded block-preparing cassette. The invention aims to reduce errors in inspection results by embedding both a biological tissue fragment and a standard substance in the same embedding agent. The method involves preparing an embedded block, slicing it to obtain a sheet-like embedded tissue slice, and selecting the tissue slice to be inspected based on a light signal from the standard substance slice. The selection is made by comparing the light signal with a calibration curve that represents the relationship between the thickness of the tissue section and the color tone of the standard substance. GlobalData’s report on Nichirei gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Nichirei, nanoemulsion cosmetics was a key innovation area identified from patents. Nichirei's grant share as of September 2023 was 19%. Grant share is based on the ratio of number of grants to total number of patents.

Tissue section selection method using marker detection for inspection

Source: United States Patent and Trademark Office (USPTO). Credit: Nichirei Corp

A recently granted patent (Publication Number: US11733131B2) describes a method for selecting a tissue section to be inspected by specifically detecting a marker. The method involves several steps, including preparing an embedded block by embedding a biological tissue fragment and a standard substance in an embedding agent. This is followed by preparing an embedded tissue section with a sheet shape by slicing the embedded block. The embedded tissue section contains both a tissue section and a standard substance section embedded in the embedding agent.

The tissue section is then selected for inspection by comparing a light signal from the standard substance section with a calibration curve. The calibration curve represents the relationship between the thickness of the tissue section and the color tone of the standard substance. If the tissue section meets a predetermined thickness, it is selected for inspection. The standard substance serves as a reference for the thickness of the tissue section.

The patent also includes additional claims related to the preparation of the embedded block. This involves placing the biological tissue fragment on the bottom of a tray and inserting the thickness standard substance into a positioning hole in an embedded block-preparing cassette. The liquid embedding agent is then poured into the tray and solidified to prepare the embedded block.

Furthermore, the standard substance mentioned in the claims can also include a marker standard substance that serves as a reference for the suitability of a marker detection result. Additionally, the standard substance can be made of a cell that expresses an endogenous protein.

In the embedded block-preparing step, the biological tissue fragment is immersed in a fixing solution for a predetermined period of time before being embedded in the embedding agent. After the embedded tissue section is prepared, a fixing state determining step is performed by comparing a light signal from an endogenous protein expressed in cells contained in the tissue section with a calibration curve. This determines the fixing state of the tissue section based on the color tone.

Overall, this patent describes a method for selecting tissue sections for inspection based on marker detection and thickness measurement. The method provides a systematic approach to ensure accurate and reliable tissue section selection in various applications, such as medical diagnostics and research.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.