Tate & Lyle has patented engineered glycosyltransferase (GT) and sucrose synthase (SuS) enzymes, along with methods for their production and use in creating products with ß-glucose linkages and rebaudiosides. The invention includes specific mutations for enhanced activity, as outlined in Claim 1. GlobalData’s report on Tate & Lyle gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Tate & Lyle, Filled confectionary manufacturing was a key innovation area identified from patents. Tate & Lyle's grant share as of February 2024 was 51%. Grant share is based on the ratio of number of grants to total number of patents.

Engineered sucrose synthase with specific mutation set for activity

Source: United States Patent and Trademark Office (USPTO). Credit: Tate & Lyle PLC

A recently granted patent (Publication Number: US11920167B2) discloses an engineered sucrose synthase with specific mutations that enhance its activity. The engineered sucrose synthase comprises a polypeptide sequence with at least 90% sequence identity to SEQ ID NO:74 and includes a mutation set at specific positions. Additionally, the patent claims cover compositions containing this engineered sucrose synthase.

Furthermore, the patent describes a method for glycosylation of substrates using the engineered sucrose synthase in combination with engineered glycosyltransferases. The method involves contacting the substrate with the enzymes under specific conditions to produce glycosylated products, such as rebaudioside M, rebaudioside A, and rebaudioside D. The process also requires the provision of NDP-glucose, which can be selected from various options like ADP-glucose and GDP-glucose. These innovative methods and compositions aim to improve the production of specific glycosylated products efficiently.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.