Kolmar Korea has been granted a patent for a pidolate salt and malate salt of a compound with excellent stability and water solubility for preventing acid pump antagonistic diseases. The method involves dissolving the compound in an organic solvent, concentrating, and filtering the solid precipitate. GlobalData’s report on Kolmar Korea gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Kolmar Korea, was a key innovation area identified from patents. Kolmar Korea's grant share as of February 2024 was 47%. Grant share is based on the ratio of number of grants to total number of patents.
Pidolate salt of compound for treating acid pump-mediated diseases
A recently granted patent (Publication Number: US11912690B2) discloses a method for preparing pidolate and malate salts of a compound represented by Formula 1. The process involves dissolving the compound and either pyroglutamic acid or malic acid in an organic solvent, concentrating the solution, adding a co-solvent, and filtering and drying the precipitated solid. The organic solvent, methanol in this case, is added in a specific volume range compared to the compound, and the co-solvent used is a mixture of acetone and ethyl acetate in a particular ratio.
In the disclosed method, the organic solvent, methanol, is added in a volume 5 to 20 times compared to the compound represented by Formula 1. Additionally, the co-solvent used is a mixed solution of acetone and ethyl acetate in a 1:4 ratio (v/v). The process involves specific steps such as concentrating the solution under decompression to precipitate a solid, followed by the addition of the co-solvent and subsequent filtration and drying of the precipitated solid. Furthermore, the malate salt preparation method follows a similar procedure with the use of L-malic acid as the co-reactant. These patented methods provide a detailed and reproducible approach for obtaining pidolate and malate salts of the specified compound, offering potential applications in various industries.
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