Kikkoman. has filed a patent for a method to enhance thermal stability of compositions containing lactate dehydrogenase. By introducing specific compounds like acids, sugars, and polymers, the method aims to improve storage stability and accuracy of lactate measuring reagents, kits, and sensors. GlobalData’s report on Kikkoman gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Kikkoman, Nanoemulsion cosmetics was a key innovation area identified from patents. Kikkoman's grant share as of January 2024 was 26%. Grant share is based on the ratio of number of grants to total number of patents.

Improving thermal stability of composition comprising lactate dehydrogenase

Source: United States Patent and Trademark Office (USPTO). Credit: Kikkoman Corp

A patent application (Publication Number: US20230365959A1) discloses a method for enhancing the thermal stability of a composition containing lactate dehydrogenase by introducing an anion such as an ionic polymer, disaccharide, dicarboxylic acid, or salt thereof. The method involves coexisting the lactate dehydrogenase with these stabilizing agents, excluding ammonium sulfate, to improve its thermal stability. The patent further specifies that the lactate dehydrogenase can be sourced from various genera such as Saccharomyces, Pichia, Candida, and others, and can have specific amino acid sequences to enhance stability.

Additionally, the patent application describes a composition for measuring lactate that includes lactate dehydrogenase requiring a flavin compound as a coenzyme along with stabilizing compounds like polycarboxylic acid, monosaccharide, tricarboxylic acid, and polyethylene glycol. The composition can be used in various applications, including lactate sensors and fuel cells. Furthermore, a method for preventing the decrease or deactivation of lactate dehydrogenase activity during the production of an electrode is detailed. This method involves applying lactate dehydrogenase to an electrode in the presence of stabilizers like ionic polymers and dicarboxylic acids to maintain enzyme activity. The electrode can then be utilized in lactate sensors to measure lactate levels accurately.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.