Firmenich International has patented a high-throughput assay system for identifying compounds that enhance olfactory receptor activity, intensifying the perception of target odorant compounds. The system involves isolated cells expressing specific olfactory receptors and compounds that positively modulate receptor activity. GlobalData’s report on Firmenich International gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Firmenich International, Nanoemulsion cosmetics was a key innovation area identified from patents. Firmenich International's grant share as of February 2024 was 50%. Grant share is based on the ratio of number of grants to total number of patents.
High-throughput assay system for identifying compounds enhancing olfactory receptors
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A recently granted patent (Publication Number: US11921105B2) discloses a high-throughput assay system designed to identify compounds that positively modulate the activity of olfactory receptors induced by specific odorant compounds. The system involves isolated cells expressing mammalian olfactory receptors, a first compound that activates the receptor, and a second compound that enhances receptor activity non-competitively. The olfactory receptor's polypeptide sequence must align with specific sequences, and the compounds used are musk or floral muguet compounds. The second compound is structurally distinct from the first and selected based on structure-activity relationship (SAR) analysis, showcasing a novel approach to identifying modulating compounds.
Furthermore, the patent details methods for identifying positive allosteric modulating compounds that enhance olfactory receptor activity in the presence of receptor agonists. By exposing cells to specific compounds and selecting those with a synergistic effect on receptor activity, the system aims to pinpoint compounds that enhance receptor function. The methods involve measuring receptor response, selecting compounds based on SAR analysis, and targeting distinct receptor sites. The patent also outlines a screening process to identify compounds that enhance the specific binding of agonist odorant compounds to olfactory receptors, potentially influencing odor perception based on their binding effects, offering a comprehensive approach to understanding olfactory modulation.
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