CJ CheilJedang has patented a modified microorganism from the genus Corynebacterium for producing L-leucine. The microorganism contains a modified polypeptide with specific amino acid substitutions and enhanced promoter for increased expression of the polynucleotide. GlobalData’s report on CJ CheilJedang gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on CJ CheilJedang, was a key innovation area identified from patents. CJ CheilJedang's grant share as of February 2024 was 61%. Grant share is based on the ratio of number of grants to total number of patents.
A recently granted patent (Publication Number: US11905539B2) discloses a modified microorganism belonging to the genus of Corynebacterium designed for producing L-leucine. The modified microorganism contains a modified polypeptide with specific amino acid substitutions, along with a resistance to norleucine or L-leucine. Additionally, the native promoter of the polynucleotide encoding the modified polypeptide is replaced with a promoter that enhances gene expression compared to the original promoter. Derived from Corynebacterium glutamicum, this modified microorganism aims to improve the production of L-leucine efficiently.
Furthermore, the patent outlines a method for producing L-leucine using the modified microorganism. The process involves culturing the microorganism in a suitable medium to generate L-leucine, followed by the recovery of the compound from the cultured microorganism or medium. By utilizing a non-native promoter, such as the PCJ7 promoter, the expression of the polynucleotide encoding the modified polypeptide is enhanced, leading to increased productivity of L-leucine. The method also includes transforming the microorganism with a vector containing the necessary genetic components for efficient L-leucine production, emphasizing the use of promoters that boost gene expression for improved yields.
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