Critiques from the International Scientific Forum on Alcohol Research
By: International Scientific Forum on Alcohol Research
The International Scientific Forum on Alcohol Research hosts forums that look at research conducted around the world on the relationship between alcohol consumption and health.
A number of prospective studies have shown that moderate drinkers are at lower risk of developing dementia or cognitive impairment than abstainers or heavy drinkers.
A recent case-control study compared the risk of having a high level of haemoglobin A1c, a measure of hyperglycemia, and of the waist/height ratio, a measure of obesity, according to reported alcohol consumption.
It has long been known that genetic and other environmental factors modify the association between alcohol consumption and a variety of diseases, especially coronary heart disease (CHD).
Excessive maternal alcohol consumption during pregnancy (especially among women with alcohol dependency) is known to markedly increase the risk of the foetus showing a group of developmental disorders defined as foetal alcohol spectrum syndrome (FASD), with the most serious form being foetal alcohol syndrome (FAS).
A recent meta-analysis was produced by authors who, in the past, have tended to argue that the demonstrated inverse association between moderate alcohol consumption and ischemic heart disease (IHD) shown in most studies is due to confounding by other lifestyle factors.
Hepatic cirrhosis frequently precedes the development of liver cancer, and excessive alcohol consumption is known to be one cause of cirrhosis.
The study concerned is based on a large number of women participating in a clinical trial (enhanced screening for certain cancers versus routine care) focusing on prostate, lung, colorectal, and ovarian cancer.
The large majority of prospective epidemiologic studies on the effects of alcohol consumption and the risk of coronary heart disease and stroke have shown a significant reduction in risk for moderate drinkers.
In a new analysis from the Nurses’ Health Study, investigators have related repeatedly-assessed long-term alcohol intake, and related the cumulative average intake over time to the risk of invasive uterine cancer.
A recent paper, which uses a very large dataset from subjects of European descent, uses a Mendelian randomisation analysis to estimate the effects of alcohol consumption on cardiovascular disease (CVD), using as the instrumental variable an uncommon allele affecting alcohol metabolism, the ADH1B rs1229984 variant.
The large European Prospective Investigation into Cancer and Nutrition Study (EPIC) has released a new analysis of the relation of alcohol consumption to mortality.
The Interheart Study is a large international collaborative project which follows individuals with a first heart attack (myocardial infarction) and compares their age- and sex-matched controls across 52 countries in Asia, Europe, the Middle East, Africa, Australia, North and South America.
An inverse or reduced risk association between moderate alcohol consumption and total mortality has been reported in most prospective epidemiologic studies, even after adjustments for all known potential confounders such as educational level, job and health.
Epidemiologists are often faced with reported adverse health effects of alcohol among subjects reporting very low levels of consumption, levels that physiologically should not cause diseases such as cancer.
A paper by Blomster JI, to be published in Diabetes Care is based on the largest study on diabetes in the world.
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